Urology Products
Instillamed®
Cost-effective 2-component protection for the bladder wall

Instillamed is a 2-component protection, instilled directly into the bladder to replace the damaged GAG layer with hyaluronic acid and chondroitin sulfate. This class III medical device is available in a sterile disposable pre-filled 50ml syringe and is instilled into the bladder via a catheter using a Luer Lock connector.

What is Instillamed?
The internal lining of the bladder wall is composed of glycosaminoglycans (GAGs), which protect it from harmful irritants in the urine. When the GAG layer is damaged, the wall loses its protection and irritants pass through into the tissue.
Instillamed has been specially developed for the temporary replacement of the protective GAG layer on the bladder epithelium and contains chondroitin sulfate and hyaluronic acid.
What is Instillamed used for?
Instillamed is instilled directly into the bladder to replace the damaged GAG layer with hyaluronic acid and chondroitin sulfate, helping to relieve the symptoms of the following conditions:
- Interstitial cystitis / Painful bladder syndrome
- Recurrent urinary tract infection / Recurrent bacterial cystitis
- Radiation cystitis
Composition
Instillamed is a bladder instillation therapy that contains 2 GAG layer components
- 800mg hyaluronic acid
- 1000mg chondroitin sulfate
Instillamed is available in a sterile disposable pre-filled 50ml syringe and is instilled directly into the bladder via a catheter using a Luer Lock connecter.
For more details, or to request a demonstration from one of our product specialists, please call 0808 1596 017 or email info@clinimed.co.uk .
Please ensure to read the full instructions for use before using this product. Instructions for use are provided with the product packaging.
How long do I need Instillamed for?
Your doctor or nurse will advise you of the duration of the treatment with Instillamed, as it varies from patient to patient. Generally, you will be given Instillamed once a week for 4 weeks, followed by monthly doses until symptoms are resolved.

Recommended exposure time
After instillation, Instillamed should be retained in the bladder until the next urination. This should be for at least 30 minutes – or longer if possible.
Storage
Do not store above 25 ◦C. Do not freeze. Keep Instillamed out of the reach and sight of children.
Clinical evaluation
The clinical evaluation below highlights some of the further benefits of using Instillamed:
An observational study was conducted on 14 patients with bladder symptoms to test the efficacy & tolerability for Instillamed for interstitial cystitis, recurring cystitis and pelvic pain syndrome. The patients with bladder symptoms for whom treatment with Instillamed was indicated took part in a prospective, monocentre, open and non-interventional study. Instillamed was administered according to the recommended instructions for use. The median observation period was 165 (155-199) days, with findings documented on 4 visits at intervals of approximately 50 days.
In this observational study, Instillamed reduced the number of micturitions, the incidence of urge incontinence and the intensity of pain. There were no documented adverse events over the duration of the study, and the efficacy and tolerability of Instillamed were rated positively by the treating physician in the majority of cases.


1. Kaufmann A, Bonn I et al. Observational study on the efficacy and tolerability of Instillamed for interstitial cystitis, recurring cystitis and pelvic pain syndrome. J Med Drug Rev 2018;8:11-22.
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